Rabbi Nussen Nuta II Ashkenazi Spira, [of Horodna, "Mavoh Shearim"]

From David Gans, Zemach David:

1576/77 Rabbi Natan of Grodno, son of my uncle, Shimshon Spira z"l......... Natan died in 5337, and he left two sons who were great in Torah: r' Isaac who was Rosh Y. in Kabla (?) and r' Issachar, who was Rosh Y. in Pinsk. And at this time he (Issachar) is Rosh Y. & AB"D in Worms [Worms Mem. p.5 and see his daughter Epidat wrm-3021 – her name is really Gelle, per Gruene Buch]

Was known as Hagaaon Rabbi Natan-Neta from Horodna. Writer of "Mavoh Shearim".

Son of Samson Spira: rabbi at Grodno; died 1577. He wrote a super commentary on the commentaries of Rashi and Elijah Mizrahi under the title of "Imre Shefer", and a commentary on the Penateuch, published by his son Isaac (Lubin, 1586 [1597]), and at the request of his pupils "Mevo She'Arim" (Lublin nd, Jessnitz 1724), a commentary on Isaac Duran's "Sha'are Durah".

Nathan That left two sons: Isaac and Israel Issachar. The Zohar was edited not by him, but by Natan ben Isaac Spira (Lublin, 1624]). Source

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• Jewish Dynasties

See also Fig. 7 in Y-DNA Genetic Signature of the Savran-Bendery Chassidic Dynasty

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Son of Samson Spira; rabbi at Grodno; died 1577. He wrote a supercommentary on the commentaries of Rashi and Elijah Mizraḥi under the title "Imre Shefer," and a commentary on the Pentateuch, published by his son Isaac (Lublin, 1586 [1597]), and at the request of his pupils "Mebo She'arim" (Lublin, n.d.; Jessnitz, 1724), a commentary on Isaac Duran's "Sha'are Durah." The Zohar was edited not by him, as Fürst and others think, but by Nathan b. Isaac Spira (Lublin, 1624). Nathan Nata left two sons: Isaac (No. 12) and Israel Issachar (No. 14).

Bibliography:
David Gans, Ẓemaḥ Dawid, ed. Offenbach, p. 30a; Jehiel Heilprin, Seder ha-Dorot, ed. Warsaw, i 248; Azulai, l.c. i. 148; De Rossi-Hamberger, l.c. p. 301; Fuenn, l.c. p. 55; Fürst, l.c. iii. 373; Zedner, Cat. Hebr. Books Brit. Mus. p. 609.

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From "Tiferes Aryeh"

AB"D Horadna and Pozna

Author of "Mevoh Shearim"

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Author of the Imrei Shefer printed in 5357 (c1597) in Lublin. During the reign of Sigismund III Vasa,

Imrei Shefer:
https://hebrewbooks.org/pdfpager.aspx?req=44619&pgnum=1

Years of Sigismund III Vasa matching the above date:
https://en.wikipedia.org/wiki/Sigismund_III_Vasa

In addition list his father as Shimshon.

Author of Commentary on Birkas Hamazon printed in Lublin in 5339 (c1579)
https://www.nli.org.il/he/books/NNL_ALEPH990017345890205171/NLI

Also lists his father as Shimshon here.

Also author of Mevo Shearim on the Shaarei Durah;
https://www.kedem-auctions.com/he/node/113264
First printing of the mevo shearim for auction - 1000$ title page states he is Nosson Ben Shimshon.

היה ידוע בכינוי הגאון רבי נתן-נטע מהורודנא, נקרא גם מהרנ"ש. בעל "מבוא שערים"

רבנו נתן נטע שפירא זצוק"ל מחבר ספר "מבוא שערים" על "שערי דורא", מגזע הקדוש רש"י ולמעלה בקודש עד התנא רבי יוחנן הסנדלר דור רביעי לרבן גמליאל הזקן בן שמעון הנשיא בן הלל הזקן מגזע שפטיה בן אביטל בן דוד מלך ישראל. ומגע הריב"ן, הטור ואביו הרא"ש וזקנו הראב"ן, הריב"ם ולמעלה בקודש.

צאצא של דון יצחק אברבנאל

https://tablet.otzar.org/#/b/105732/p/122/t/1690954153145/fs/M1XJol...